Metabolism changes with age, just not when you might think

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Most of us remember a time when we could eat anything we wanted and not gain weight. But a new study suggests your metabolism, the rate at which humans burn calories, actually peaks much earlier and starts its inevitable decline later than previously thought. The findings suggest that other factors lie behind the so-called “middle-age spread.”

“As we age, there are a lot of physiological changes that occur in the phases of our life such as during puberty and in menopause. What’s odd is that the timing of our ‘metabolic life stages’ doesn’t appear to match the markers we associate with growing up and getting older,” said study co-author Jennifer Rood, PhD, Associate Executive Director for Cores and Resources at Pennington Biomedical Research Center.

Four Pennington Biomedical researchers were part of an international team of scientists who analysed the average calories burned by more than 6,600 people as they went about their daily lives. The participants’ ages ranged from one week old to 95 years, and they lived in 29 different countries. The other Pennington Biomedical scientists are Peter Katzmarzyk, PhD, Associate Executive Director for Population and Public Health Sciences; Corby Martin, PhD, Professor and Director, Ingestive Behaviour Laboratory; and Eric Ravussin, PhD, Associate Executive Director for Clinical Science.

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Most previous large-scale studies measured how much energy the body uses for basic vital functions — breathing, digesting, and pumping blood — the calories needed just to stay alive. But basic functions account for just 50 percent to 70 percent of the calories we burn each day. They don’t include the energy we spend doing everything else: washing the dishes, walking the dog, breaking a sweat at the gym, even just thinking or fidgeting.

To come up with a number for total daily energy expenditure, the researchers turned to the “doubly labelled water” method. It’s a urine test that involves having a person drink water in which the hydrogen and oxygen in the water molecules have been replaced with naturally occurring “heavy” forms, and then measures how quickly they are flushed out.

Scientists have used the technique — considered the gold standard for measuring daily energy expenditure during normal daily life outside of the lab — to measure energy expenditure in humans since the 1980s. But previous studies were limited in size and scope due to cost. To get around that limitation, multiple labs shared their data in a single database, to see if they could tease out truths hidden or only hinted at in previous studies.


Pooling and analysing energy expenditures across the entire lifespan revealed some surprises.

“Some people think of their teens and 20s as the age when their calorie-burning potential hits its peak,” Dr. Katzmarzyk said. “But the study shows that, pound for pound, infants had the highest metabolic rates of all.”

Energy needs shoot up during the first 12 months of life. By their first birthdays, babies burn calories 50 percent faster for their body size than adults.


And that is not just because infants are busy tripling their birth weight in their first year.

“The babies grow rapidly, which accounts for much of the effect. However, after you control for this, their energy expenditures tend to be higher than what you would expect for their body size,” Dr. Martin said.

An infant’s explosive metabolism may help explain why children who do not get enough to eat during this developmental stage are less likely to survive and grow up to be healthy adults.

“More research is needed to better understand the metabolism of babies. We need to know what is driving higher energy expenditures,” Dr. Martin said.

After the initial surge in infancy, a person’s metabolism slows by about 3 percent each year until our 20s, when it levels off into a new normal.

Surprisingly, the growth spurts of adolescence did not generate an increase in daily calorie needs after researchers took body size into account. Another surprise? People’s metabolisms were most stable from their 20s through their 50s. Calorie needs during pregnancy grew no more than expected.

The findings suggest that other factors lie behind the so-called “middle-age spread.”

The data suggest that our metabolisms do not really start to decline again until after age 60. The slowdown is gradual, only 0.7 per cent a year. But a person in their 90s needs 26 per cent fewer calories each day than someone in midlife.

Lost muscle mass as we get older may be partly to blame, the researchers say, since muscle burns more calories than fat. But it’s not the whole picture.

“We took dwindling muscle mass into account. After 60, a person’s cells slow down,” Dr. Ravussin said.

The patterns held even when differing activity levels were taken into account.

Aging goes hand in hand with so many other physiological changes that it has been difficult to parse what drives the shifts in energy expenditure. But the new research supports the idea that it is more than age-related changes in lifestyle or body composition.

“This study shows that the work cells do changes over the course of the lifespan in ways we couldn’t fully appreciate before. But massive data sets like the one we collaborated on allow us to answer questions we couldn’t address,” Dr. Ravussin said.


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Deirdre Tynan is an award-winning journalist who enjoys bringing the best in news reporting to Spain’s largest English-language newspaper, Euro Weekly News. She has previously worked at The Mirror, Ireland on Sunday and for news agencies, media outlets and international organisations in America, Europe and Asia. A huge fan of British politics and newspapers, Deirdre is equally fascinated by the political scene in Madrid and Sevilla. She moved to Spain in 2018 and is based in Jaen.

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