Gene Variants May Dictate Severity of Coronavirus

Scientists had guessed that unknown factors were clearly leaving some people vulnerable to the pandemic’s worst effects even though some of them were young, were not overweight, and did not suffer from other obvious health problems. Scientists now think that tiny genetic differences are causing some to be struck down while many others are spared.

Differences in DNA are now being tracked by researchers who believe they offer a route to developing new drugs that could halt many of the worst consequences of suffering from COVID-19.

“These genetic findings give us very clear insights,” said Martin Hibberd, professor of emerging infectious diseases at the London School of Hygiene and Tropical Medicine. “They are natural biological experiments which suggest that people who make more interferon when infected have a better response to the disease. And that, in turn, tells us that patients could well benefit from treatment with interferon.”

It is not know how long it would be until a drug trial using interferon could be started as many obstacles are still to be overcome.

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