Interpol Launches DNA Database To Solve Cold Cases

Interpol launches a DNA database to solve cold cases by examining family DNA

IN 2004, Croatian police found a man’s body in the Adriatic Sea. The condition of the body, which rendered identification through fingerprints or facial recognition impossible, meant that – for more than a decade – it remained unidentified.

Enter I-Familia, a ground-breaking new database officially launched on June 1 that applies cutting-edge scientific research and uses the DNA of relatives to identify missing persons or unidentified human remains around the world.

In late 2020, DNA from the children of an Italian man missing since 2004 was added to I-Familia and then checked against DNA from all unidentified human remains in the system.  A match was found between the children’s DNA and that of the body found in the Adriatic Sea, closing a case that had gone cold 16 years earlier.

Global database for kinship matching

“Family members’ DNA profiles can be compared to that of an unidentified body or human remains through what is known as DNA kinship matching. This method is often used when a direct sample from the missing person – from a prior medical sample or a personal item such as a toothbrush – is not available,” Interpol said in a statement.

However, complex calculations are required to confirm a match because biological relatives share differing percentages of the DNA. This complexity is magnified when undertaken at the international level, due to the genetic variation among populations across the world.

I-Familia is the first global database to automatically control for such differences without requiring knowledge of the missing person’s genetic ancestry and provide standardised guidelines on what constitutes a match.

“Identifying missing persons globally has always been challenging, due to the lack of data exchange procedures combined with the scientific complexity of statistical interpretation,” said Dr Arnoud Kal, senior forensic scientist at the Netherlands Forensic Institute – one of the world’s leading forensic laboratories.

“We believe the development by Interpol of I-Familia opens up new opportunities for member countries that will positively impact the effectiveness of international missing person investigations,” Dr Kal added.

The missing, and the impact on their families

A countless number of individuals go missing globally each year due to crime, conflicts, accidents or natural disasters. By late 2020, over 12,000 active Yellow Notices – international police alerts for missing persons – had been issued by the Interpol General Secretariat.

For families facing the uncertainty of whether their loved ones are alive or dead, sometimes for many years, the emotional toll can be crushing. The absence of a death certificate can also have considerable administrative and financial implications.

“All countries have unsolved missing persons investigations as well as human remains that cannot be identified using their national systems alone,” said Interpol Secretary General Jürgen Stock.

“I-Familia is a humanitarian tool which, enabled by Interpol’s global reach, opens up vast new possibilities to identify missing persons and to provide families with answers,” he added.

How I-Familia works

DNA profiles are submitted by Interpol’s 194 member countries to make links between missing persons and cases related to human remains.

I-Familia is made up of three components: A dedicated global database to host the DNA profiles provided by relatives, held separately from any criminal data; DNA matching software, called Bonaparte, developed by Dutch company Smart Research; Interpretation guidelines, produced by Interpol, to efficiently identify and report potential matches.

The Bonaparte technology uses advanced statistical algorithms to calculate the probability of a match compared against an interpretation table. This powerful software can perform millions of calculations in a short space of time. The result is then interpreted by forensic DNA experts at the Interpol General Secretariat.

In the event of a match, notifications are sent to the countries that supplied the DNA profile from the unidentified body and from the family respectively. Further checks, such as dental records and personal belongings, can then be carried out to confirm the potential match.

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